The Rams will welcome the Welsh side to Pride Park in the first of twenty-three home league games in the 2019/20 season.
Phillip Cocu will be hoping his side will build on their 2-1 victory over Huddersfield in order to make an early push for promotion into the Premier League.
The Swans finished 10th last season in their first season back in the second division with Graham Potter.
Since then, Potter has taken the leap to Brighton, meaning Steve Cooper has since been tasked with the job of getting Swansea back into the Premier League.
Cooper has made six summer signings and got off to the perfect start as they made a quick comeback to beat Hull City 2-1 at the Liberty Stadium to grant the new manager his first points of the season.
The two sides faced off twice last season in the league, with both games being very close encounters. The first of which was at Pride Park where Derby managed a 2-1 victory, despite a late onslaught of pressure from the visitors.
The second was in early May, where the game ended in a 1-1 draw that meant Derby had to go and beat West Brom to confirm a play-off place at the end of the season.
Phillip Cocu confirmed that Krystian Bielik will be unavailable once again due to a late pre-season after coming back from international duty with the Poland Under-21’s.
The Rams manager also mentioned that a few players picked up knocks from Monday’s trip to Huddersfield, but the squad should all be fine to be involved at Pride Park on Saturday.
Cooper confirmed that Andre Ayew is back at Swansea but will miss out on Saturday’s fixture to have extra time to recover from international duty but there is a chance that Wayne Routledge returns for the Swans after missing out on the Hull game.
Phillip Cocu expressed his eagerness ahead of his first game at Pride Park and said: “It's the first home game and we will do everything we can to make it a good game and get a good result,”
Cocu was also very quick to discuss his style of play and philosophy, saying: “Every game the details will change a little bit. The general playing style will change, because it is our philosophy and the way we want to play.
“Sometimes, depending on the opponent, or for a home or away game, or for types of players there are minor adjustments to the team.”